An update in toxicology of ageing
Environmental Toxicology and Pharmacology（2021）
摘要
•Certain environmental factors can substantially increase pace of ageing.•They include sun exposure, pollution, unhealthy lifestyle and cytotoxic therapies.•Their gerontogenic mechanisms involve ROS, inflammation and loss of proteostasis.•The SA-biomarkers are broadly used, however, not yet perfect ageing biomarkers.•Some gerontogens might, paradoxically, confer protection at certain conditions.
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ADLs,A(Ep)RE,AFAR,AGEs,ALP,AMP,AMPK,AP-1,ARE,ARF,ART,ATM,AUD,AZM,BMI,CAT,CDK,CMA,CMV,CNC,COPD,COVID-19,COX-2,CQ,cPLA2,CR,CS,CSA,CVD,DDR,DM,DNA,DNAm,DNAmAge,DMAE,ERKs,EtOH,FOXO,FRTA,FT3,FT4,GDF15,GH,GPx,GR,H2O2,HAART,HDL,HIV,HO-1,HPA,Hsc70,HSFs,Hsps,i20S,ICAM—1,IF,IGF-1,IgG,IGT,IL-1β,IL6,iNOS,IR,JNKs,Lamp2A,LDL,LTL,MAP2K3,MDA,MetS,MHC-I,miRNAs,MMP9,mtDNA,mthtt,mtROS,mTOR,NAD(P)H,NF-κB,NGT,NQO1,Nrf-2,NRTI,NT-proBNP,p38 MAPK,PD,PGC1α,PI3K,PKC,PM2.5,QoL,Raf,Ras,ROS,rSDS-PrPSc,SASP,SDS,SERPINs,SFK,SIPS,SIRT1,SOD,STC1,TAFs,T2DM,TIS,TL,TNF-α,TRF,TSH,T/S ratio,Ubb+1,UC,UPS,UV,VCAM-1,VO2peak,WHO
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