Cathelicidin Delta Pb-Cath4 Derived From Python Bivittatus Accelerates The Healing Of Staphylococcus Aureus-Infected Wounds In Mice

The effects of Delta Pb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus-infected wounds in mice. These effects were comparable to those of classical antibiotics. Delta Pb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, Delta Pb-CATH4 can promote wound healing by controlling infections including those caused by multidrug-resistant bacteria via its immunomodulatory effects.