Chrome Extension
WeChat Mini Program
Use on ChatGLM

Virus-Encoded Complement Regulators: Current Status

Anwesha Sinha,Anup Kumar Singh, Trupti Satish Kadni,Jayati Mullick,Arvind Sahu

VIRUSES-BASEL(2021)

Cited 5|Views4
No score
Abstract
Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and boosting the antiviral innate and acquired immune responses. Thus, the system imposes a strong selection pressure on viruses. Consequently, viruses have evolved multiple countermeasures against host complement. A major mechanism employed by viruses to subvert the complement system is encoding proteins that target complement. Since viruses have limited genome size, most of these proteins are multifunctional in nature. In this review, we provide up to date information on the structure and complement regulatory functions of various viral proteins.
More
Translated text
Key words
viral immune evasion, complement, innate immunity, pathogenesis, Poxvirus, Herpesvirus, RCA, CD59, viral RCA
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined