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Selective alkylation of parallel G-quadruplex structure

Kazumitsu Onizuka, Erchissaran Ganbold,Yue Ma,Shogo Sasaki,Madoka E Hazemi,Yutong Chen,Norihiro Sato,Mamiko Ozawa,Kazuo Nagasawa,Fumi Nagatsugi

Organic & Biomolecular Chemistry（2021）

Cited 4|Views10
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Abstract
The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).
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Key words
selective alkylation,parallel,g-quadruplex
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