Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 mu M against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.