Breakthrough Candidemia In Pediatric Patients With Cancer From A Brazilian Center

Anna Carlota Mott Barrientos,João Nobrega de Almeida Junior,Nadia Litvinov,Vera Bain,Lilian Maria Cristofani,Maria Fernanda Badue Pereira,Camila Sanson Yoshino de Paula,Adriana Lopes Motta,Flavia Rossi,Gilda Maria Bárbaro Del Negro,Danilo Yamamoto Thomaz,Heloisa Helena Sousa Marques

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2021）

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Abstract

We analyzed 19 cases of breakthrough candidemia from a referral pediatric cancer center in Brazil. All patients had neutropenia and were under antifungal prophylactic regimens, mostly micafungin (68%). Most of the patients were treated with amphotericin B formulations and 30-day mortality was 21%. Candida parapsilosis was the main etiologic agent (63%), and horizontal transmission was not evidenced by microsatellite analysis.

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Key words

candidemia, neutropenia, children, Candida parapsilosis, antifungal susceptibility

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