A Guide To Directing Group Removal: 8-Aminoquinoline
CHEMISTRY-A EUROPEAN JOURNAL(2021)
摘要
The use of directing groups allows high levels of selectivity to be achieved in transition metal-catalyzed transformations. Efficient removal of these auxiliaries after successful functionalization, however, can be very challenging. This review provides a critical overview of strategies used for removal of Daugulis' 8-aminoquinoline (2005-2020), one of the most widely used N,N-bidentate directing groups. The limitations of these strategies are discussed and alternative approaches are suggested for challenging substrates. Our aim is to provide a comprehensive end-users' guide for chemists in academia and industry who want to harness the synthetic power of directing groups-and be able to remove them from their final products.
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关键词
C−, H activation, directing groups, homogeneous catalysis, hydrolysis, synthetic methods
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