Immunity, Aging, and the Works of V.M. Dilman

The review is dedicated to the anniversary of the birth of the brilliant gerontologist, endocrinologist, and oncologist Vladimir Mikhailovich Dilman. It provides a historical analysis of the hypotheses of immunocooperative interactions, which have been given a prominent place in his original concept of aging. The history of various T-cell populations and subpopulations is reviewed, and their functions are briefly analyzed in relation to age-specific changes in immunity. Also considered is the theory of inflammaging in light of the concept of V.M. Dilman.