Immunity, Aging, and the Works of V.M. Dilman
ADVANCES IN GERONTOLOGY(2021)
Abstract
The review is dedicated to the anniversary of the birth of the brilliant gerontologist, endocrinologist, and oncologist Vladimir Mikhailovich Dilman. It provides a historical analysis of the hypotheses of immunocooperative interactions, which have been given a prominent place in his original concept of aging. The history of various T-cell populations and subpopulations is reviewed, and their functions are briefly analyzed in relation to age-specific changes in immunity. Also considered is the theory of inflammaging in light of the concept of V.M. Dilman.
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Key words
T lymphocytes, subpopulations of T-helper cells, aging, inflammaging, V.M. Dilman
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