Antibodies to an Epstein Barr Virus protein that cross-react with dsDNA have pathogenic potential

•Monoclonal Antibodies to EBNA-1, that cross-react with dsDNA.•Can bind to isolated glomeruli and can deposit in the kidney when injected into mice.•Can induce proteinuria and histopathologic alterations in the kidney consistent with glomerulonephritis.•Can bind extracellular matrix antigens found in the GBM and mesangial matrix.•Have pathogenic potential and may play a significant role in triggering SLE and lupus nephritis.