ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy

Rong Jiang, Lei Han,Qianqian Gao,Jie Chao

Environmental Toxicology and Pharmacology（2021）

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摘要

•SiO2 induce EndoMT and ZC3H4 expression in endothelial cells and lung vessels.•The knockdown of ZC3H4 could attenuate SiO2-induced EndoMT in pulmonary fibrosis.•ZC3H4 mediates EndoMT via endoplasmic reticulum stress (ER stress) and autophagy.•ZC3H4 may become a novel target in silicosis treatment.

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关键词

EndoMT,EMT,SiO2,HUVEC,VE-cad,Col1,α-SMA,NS,ER stress

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