ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy
Environmental Toxicology and Pharmacology(2021)
摘要
•SiO2 induce EndoMT and ZC3H4 expression in endothelial cells and lung vessels.•The knockdown of ZC3H4 could attenuate SiO2-induced EndoMT in pulmonary fibrosis.•ZC3H4 mediates EndoMT via endoplasmic reticulum stress (ER stress) and autophagy.•ZC3H4 may become a novel target in silicosis treatment.
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关键词
EndoMT,EMT,SiO2,HUVEC,VE-cad,Col1,α-SMA,NS,ER stress
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