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Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells

Xuyan Tian,Lipeng Tang,Fengjiao Wei,Huanpeng Chen,Longxiang Sheng,Yuying Yang,Xiaoqing Zhou,Yongchao Li,Xiaoting Xu,Boyang Zhang,Zhonghua Liu,Yu Lei,Bolan Yu,Chuan Bai,Xixin He,Zhaofeng Huang

Molecular Immunology（2021）

Cited 5|Views11
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Abstract
•PPY-3, PPY-4 and PPY-5 could alleviate the clinical symptoms psoriatic dermatitis.•PPY-3, PPY-4, PPY-5 inhibit proliferation of keratinocytes by reducing inflammation.•PPY-3, PPY-4, PPY-5 inhibits Th17 by inhibiting RORγt to suppress skin inflammation.
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Pentacyclic triterpene,Psoriasis,RORγt,Th17 cells
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