Old Rats Are More Susceptible to Induction of Benign Prostatic Hyperplasia (BPH) at Comparative to Young Mature.

Vladimir G Bespalov,Valerij A Alexandrov,Alexander L Semenov,Grigory V Tochilnikov,Elena D Ermakova,Yuliya G Zmitrichenko,Irina N Vasilyeva, Alexandеr O Ivantsov,Nadezhda T Zhilinskaya

Current aging science（2021）

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摘要

Our experimental model indicates the important role of non-bacterial prostatitis in the pathogenesis of BPH. No metabolic disorders in BPH induction were revealed. The sensitivity of the prostate of old rats to BPH development is increasing despite the low concentrations of testosterone in the body. Age sensitivity to BPH is probably determined by a higher expression of androgen receptors in old animals.

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关键词

Young and old rats,age-dependent sensitivity,benign prostatic hyperplasia,inflammation,testosterone.

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