Flapless Application of Enamel Matrix Derivative in Periodontal Retreatment: A Multicentre Randomized Feasibility Trial
Journal of clinical periodontology(2021)
摘要
Aim To investigate the potential benefit of enamel matrix derivative (EMD) as adjunct to re-instrumentation of residual pockets persisting after steps 1 and 2 of periodontal therapy. Material and Methods 44 adult patients participated in a multicentre feasibility randomized clinical trial with split-mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for generalized periodontitis with at least 2 teeth with residual probing pocket depths (PPD) >= 5 and <= 8 mm, with bleeding on probing (BOP). Two teeth with similar PPD were randomized to receive re-instrumentation either with (test) or without (control) adjunctive flapless administration of EMD. Differences in the changes of PPD and BOP from baseline to 6 and 12 months were analysed, and the frequencies of pocket closure (PPD <= 4 mm and no BOP) compared. Results For the primary outcome "change of mean PPD after 6 months," a significant additional benefit of 0.79 +/- 1.3 mm (p < .0001) could be observed for the test group. At 12 months, this difference could be maintained (0.85 +/- 1.1 mm; p < .0001). The frequency of pocket closure in the test group was 69% at 6 and 80% at 12 months and significantly higher than in the control group with 34% and 42%, respectively (p < .01). Conclusions The results of the present feasibility study indicate a benefit of adjunctive EMD during non-surgical retreatment (step 3 of periodontal therapy) of residual deep pockets.
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关键词
enamel matrix derivative,periodontitis,re‐,instrumentation,retreatment,scaling and root planing
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