Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation

Cheng Zhang, Xin Li,Xiang Hu,Qirui Xu,Yanqi Zhang,Hongyan Liu,Yutao Diao,Xiaoyu Zhang,Lianlian Li,Jie Yu,Haipeng Yin,Jun Peng

International Immunopharmacology（2021）

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摘要

•EGCG inhibits NLRP3 inflammasome activation.•EGCG blocks NLRP3-mediated ASC speck formation and pyroptosis.•EGCG plays a role in preventing NLRP3 inflammasome-dependent inflammation in a mouse model of T2D.•EGCG improves diabetes-induced glucose tolerance in vivo.

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关键词

EGCG,NLRP3,Inflammasome,IL-1β,ASC,Glucose tolerance

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