Generation of an induced pluripotent stem cell line (SIAISi009-A) from a 60-year-old Chinese Han female with mild cognitive impairment (MCI) having two copies of APOE4/4 allele.

Induced pluripotent stem cells play vitally essential roles in regenerative medicines for disease modeling and drug screening. Here, we successfully generated an iPSC line from PBMC of a 60-year-old female with mild cognitive impairment in an APOE 4/4 background to better understand studies relating to MCI and other cognitive diseases. In the newly-developed hiPSC line SIAISi009-A, all pluripotent markers were well expressed. Moreover, cells displayed a normal karyotype and have differentiation potential proven by in vitro trilineage differentiation method.