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Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Kien Tran,Robin Van den Hauwe,Xavier Sainsily,Pierre Couvineau,Jerome Cote, Louise Simard, Marco Echevarria,Alexandre Murza, Alexandra Serre,Lea Theroux,Sabrina Saibi,Lounes Haroune,Jean-Michel Longpre,Olivier Lesur,Mannix Auger-Messier,Claude Spino,Michel Bouvier,Philippe Sarret,Steven Ballet,Eric Marsault

Journal of Medicinal Chemistry（2021）

Cited 12|Views35
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