Molecular characterization of clinical isolates of Enterobacterales with elevated MIC values for aztreonam-avibactam from the INFORM global surveillance study, 2012–2017

•WGS queried resistance mechanisms for aztreonam-avibactam in Enterobacterales.•Insertions in PBP3 found in E. coli isolates with aztreonam-avibactam MIC ≥ 2 μg/mL.•Avibactam-insensitive PER in some isolates with aztreonam-avibactam MIC ≥ 8 μg/mL.