A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

Alyssa Silva-Cayetano,William S Foster,Silvia Innocentin,Sandra Belij-Rammerstorfer,Alexandra J Spencer,Oliver T Burton,Sigrid Fra-Bidó,Jia Le Lee,Nazia Thakur,Carina Conceicao,Daniel Wright,Jordan Barrett,Nicola Evans-Bailey, Carly Noble,Dalan Bailey,Adrian Liston,Sarah C Gilbert,Teresa Lambe,Michelle A Linterman

Med（2021）

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摘要

ChAdOx1 nCoV-19 induces spike-specific polyfunctional CD8+ and CD4+ T cellsChAdOx1 nCoV-19 stimulates extrafollicular plasma cell and germinal center formationA single dose of ChAdOx1 nCoV-19 induces cellular and humoral immunity in aged miceA booster dose of ChAdOx1 nCoV-19 enhances immunogenicity in aged mice

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