Radiation-Induced Eosinophils Improve Cytotoxic T Lymphocyte Recruitment And Response To Immunotherapy
SCIENCE ADVANCES(2021)
摘要
The efficacy of cancer immunotherapy is dictated by CD8(+) T cell infiltration and the nature of the tumor micro-environment (TME). By inflaming the TME to favor CD8(+) T cell immunity, radiation is now widely considered as a neoadjuvant for immunomodulation. Here, we observed that local irradiation enhances the infiltration of intratumoral eosinophils, and depletion of eosinophil dampens CD8(+) T cell infiltration and diminishes the anti-tumor effectiveness of radiation. Retrospectively, we identified a strong correlation between eosinophilia and survival benefit in radiation-treated cancer patients. Experimentally, we further show that radiation enhances the intra-tumoral infiltration of adoptive transferred T cells therapy, bolstering eosinophils by intravenous interleukin-5 administration promotes the efficacy of radiation-induced abscopal effect. Together, these results suggest that eosinophil mobilization can be considered as a mechanistically relevant biomarker for predicting the effectiveness of pre-immunotherapy radiation, as well as a new strategy to enhance T cell-mediated immunotherapy against cancers.
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关键词
eosinophils,immunotherapy,radiation-induced
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