Sars-Cov-2 Spike Protein Positivity In Pityriasis Rosea-Like And Urticaria-Like Rashes Of Covid-19

The spike (S) protein of SARS-CoV-2 is responsible for receptor recognition and cell membrane fusion.1 Positive immunohistochemistry (IHC) for SARS-CoV/SARS-CoV-2 spike protein has been found in lungs, tracheal mucosa, renal tubular epithelial cells, and recently in chilblain-like and erythema multiforme-like lesions of patients with COVID-19.2 Herein, we report on two patients, one with a pityriasis rosea-like rash, and one with an urticarial rash with positive IHC for SARS-CoV/SARS-CoV-2 spike protein.