Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla
Journal of Asian Natural Products Research(2021)
Abstract
Six new triterpenes, uncarinic acids K–P (1–6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the (E)-/(Z)-coumaroyloxy and (E)-/(Z)-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.
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Key words
Rubiaceae,Uncaria rhynchophylla,triterpene,uncarinic acids K–P
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