Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla

Journal of Asian Natural Products Research(2021)

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Abstract
Six new triterpenes, uncarinic acids K–P (1–6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the (E)-/(Z)-coumaroyloxy and (E)-/(Z)-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.
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Key words
Rubiaceae,Uncaria rhynchophylla,triterpene,uncarinic acids K–P
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