Characterization of interactions between local anesthetics and histamine H1 receptor by cell membrane chromatography model

Jiao Cao,Liu Yang,Yuejin Wang,Rui Liu,Tao Zhang,Langchong He

Journal of Pharmaceutical and Biomedical Analysis（2021）

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摘要

•The KD values of local anesthetic were measured by H1R-HEK293/CMC model.•Different local anesthetic exhibit different binding to H1R with that of histamine.•The first report characterizing the interaction of local anesthetic to H1R by CMC.

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关键词

CMC,CMSP,H1R,KD

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