Chemerin impairs food intake and body weight in chicken: Focus on hypothalamic neuropeptides gene expression and AMPK signaling pathway
General and Comparative Endocrinology(2021)
摘要
•CMKLR1 protein levels are higher in chicken hypothalamus than chemerin, GPR1 and CCRL2.•Peripheral daily chemerin injections decrease chicken food intake and body weight.•Chemerin increases chicken plasma insulin whereas it decreases glucose levels.•Chemerin decreases the hypothalamic orexigenic neuropetides Npy and AgRP mRNA expression.•Chemerin decreases hypothalamic CMKLR1 protein expression and AMPK activation.
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关键词
Chemerin,Food intake,Hypothalamic gene,Chicken
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