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Anorectal Transplantation: The First Long-Term Success in a Canine Model

Jun Araki,Yuji Nishizawa,Naoki Fujita,Tomoyuki Sato,Tomoya Lizuka,Masatoshi Komata,Naoyuki Hatayama,Tomiko Yakura,Shuichi Hirai,Kensuke Tashiro,Flavio H F Galvão,Tatsuo Nakamura,Masahiro Nakagawa,Munekazu Naito

DISEASES OF THE COLON & RECTUM（2022）

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Abstract
We describe the critical role of the pudendal nerve in anorectal function and the first long-term success with anorectal transplantation in a canine model. This report is a proof-of-concept study for anorectal transplantation as a treatment for patients with an ostomy because of anorectal dysfunction.
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anal reconstruction, anorectal transplantation, colostomy, functional recovery, preclinical animal experiment, vascularized composite tissue allotransplantation
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