Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

•Mice deficient in ketohexokinase (KHK) show reduced features of NASH on a high-fat/high-fructose diet.•KHK inhibition reduces lipogenic gene expression in the presence of high fructose/glucose.•Activated myofibroblasts show reduced expression of fibrogenic genes when treated with KHK inhibitor.•KHK inhibitor reduced hepatic accumulation of lipogenic fructose derivatives and glycolysis in human liver.