The role of EphB4/ephrinB2 signaling in root repair after orthodontically-induced root resorption

•EphB4/ephrinB2 signaling activity was found during physiological root regeneration.•Inhibition of signaling hindered the formation of new cementum after heavy forces in rats.• EphB4/ephrinB2signaling is essential for the regeneration of orthodontically-induced root resorption.•EphB4/ephrinB2 signaling helps speed the repair of orthodontically-induced root resorption.