Percutaneously-quantified advanced glycation end-products (AGEs) accumulation associates with low back pain and lower extremity symptoms in middle-aged low back pain patients

•We evaluated how AGEs associate with clinical symptoms and comorbidities.•AGEs were accumulated in aged patients especially with diabetes, dialysis, or osteoporosis.•In the LBP patients under 50 years old, AGEs were positively correlated with clinical symptoms.•If AGEs accumulate since young era, watch out for future osteoporosis and clinical symptoms.