Transcription, Translation, And Dna Repair: New Insights From Emerging Noncanonical Substrates Of Rna Helicases
BIOLOGICAL CHEMISTRY(2021)
Abstract
RNA helicases are enzymes that exist in all domains of life whose canonical functions include ATP-dependent remodeling of RNA structures and displacement of proteins from ribonucleoprotein complexes (RNPs). These enzymes play roles in virtually all processes of RNA metabolism, including pre-mRNA splicing, rRNA processing, nuclear mRNA export, translation and RNA decay. Here we review emerging noncanonical substrates of RNA helicases including RNA-DNA hybrids (R-loops) and RNA and DNA G-quadruplexes and discuss their biological significance.
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Key words
DEAD-box helicase, DEAH-box helicase, G-quadruplexes, R-loops, RNA-DNA hybrid, RNA helicase
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