SYNTHESIS OF ROCHE LACTONE VIA THE ENANTIOSELECTIVE ALCOHOLYSIS OF meso-CYCLIC ANHYDRIDE STRATEGY: A PRACTICAL APPROACH EMPLOYING AN EFFICIENT AND REUSABLE ORGANIC MICROGEL AUXILIARIES

Roche lactone, a key chiral intermediate of the natural water-soluble B series vitamin (+)-biotin, was synthesized from meso-cyclic anhydride in overall yield 78% through three steps, including heterogeneous asymmetric desymmetrization, chemoselective reduction and lactonization.