Novel Benzimidazole- Platinum(II) Complexes: Synthesis, Characterization, Antimicrobial and Anticancer Activity

Umut Doğan, Özge Özcan, Gizem Alaca, Aydan Arı,Salih Günnaz,H. Tansel Yalçın,Onur Şahin,Sevil İrişli

Journal of Molecular Structure(2021)

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摘要
•New three Platinum complexes (1-3) with 2,6-di-tert-butyl-4-(1-phenyl-1H-benzimidazol-2-yl) phenol (L1), N, N-dimethyl-4-(1-phenyl-1H-benzimidazol-2-yl) aniline (L2) and 4-(1H-benzimidazol-2-yl)-N, N-dimethylaniline (L3) were synthesized.•The crystal structures of L1, 1 and geometrical isomer of 1 (1a) were determined by X-Ray crystallography.•The cytotoxic activities of the compounds were tested on against SHSY-5Y and U-87 cell lines and antimicrobial effect on gram positive and gram negative bacteria.
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关键词
Benzimidazole,Benzimidazole platinum (II) complexes,Cytotoxicity,Antimicrobial activity
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