Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur
Mendeleev Communications(2020)
摘要
Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.
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关键词
fungicides,medicinal chemistry,arenesulfonamides,Malassezia furfur,seborrheic dermatitis
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