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Rivaroxaban enhances thrombin-induced endothelial progenitor cell activation

S. Papadaki,S. Sidiropoulou,V. Chantzichristos, A.D. Tselepis

Atherosclerosis（2020）

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Abstract
Background and Aims: Factor Xa (FXa) and thrombin exert non-haemostatic cellular effects. Late-outgrowth endothelial cells (OECs) are a type of endothelial progenitor cells. We investigated the effect of rivaroxaban, a direct oral anticoagulant which specifically inhibits FXa’s activity, on FXa-and thrombin-induced OEC activation, using as activation markers the ICAM-1 membrane expression and MCP-1 secretion.
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thrombin-induced
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