POSITIVE TPOAB AND TGAB ARE ASSOCIATED WITH BETTER CLINICOPATHOLOGIC FEATURES OF PTC

Abstract Objective The aim of this study was to compare the thyroid autoantibody status of patients with papillary thyroid cancer (PTC) and benign nodular goiter, as well as possible associations between thyroid autoantibodies and clinicopathologic features of PTC. Methods A total of 3,934 participants who underwent thyroidectomy were enrolled in this retrospective study. Patients were divided into PTC and benign nodule groups according to pathological diagnosis. Preoperative serum antibody results were used to segregate PTC patients into TPOAb positive, TgAb positive, dual TPOAb and TgAb positive, or antibody negative. Results Of the 3,934 enrolled patients, 2,926 (74.4%) were diagnosed with PTC. Multivariate regression analyses suggested that high TSH levels (adjusted OR=1.732, 95%CI (1.485-2.021), p Conclusion Although preoperative positive TPOAb and TgAb are independent predictive markers for PTC, they are also associated with better clinicopathologic features of PTC.