Insights of Tris(2-pyridylmethyl)amine as anti-tumor agent for osteosarcoma: experimental and in silico studies

Marcos V. Palmeira-Mello, Juliana Lima Souza,Anthuan Ferino Pérez,Amanda dos Santos Cavalcanti,Suzana Assad Kahn,Nady Passe-Coutrin,Idania Rodeiro Guerra,Antonio Doménech-Carbó,Ulises Javier Jauregui-Haza,Alessandra Mendonça Teles de Souza,Mauricio Lanznaster,Gerardo Cebrián-Torrejón

Journal of Molecular Structure（2021）

引用 2|浏览10

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摘要

•TPA presents antitumor activity against MG-63 and Saos-2 osteosarcoma cells.•DNA-interacting studies by cyclic voltammetry were performed.•Molecular docking studies were conducted for DNA and other biological targets.•Good pharmacokinetic and toxicological profile obtained via ADMET in silico analysis.

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关键词

osteosarcoma,anti-tumor

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