Xad Resins For Increased Rebeccamycin Productivity In Cultivations Of Lentzea Aerocolonigenes
CHEMIE INGENIEUR TECHNIK(2021)
Abstract
Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. For a medical application maximized titers and appropriate downstream processing are necessary. The addition of the adsorbents XAD 4, XAD 17 HP, and XAD 16 N was investigated for increased productivity and in situ product recovery. An increase in product titer was observed for XAD 7 HP and XAD 16 N. A combination of these particles with glass beads led to a further increase. Moreover, rebeccamycin can be adsorbed to these particles which facilitate the extraction since the liquid phase can be dispensed with.
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Key words
Adsorption, Filamentous microorganism, Glass beads, Rebeccamycin, XAD adsorbent resins
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