Abstract 117: Transgelin: A New Gene Involved in LDL Endocytosis in Liver Cells Identified by a Whole-genome Crispr-cas9 Screen

Diego Lucero,Michael Mendelson, Promotto Islam,Lita A Freeman,Edward B Neufeld,Jingrong Tang,Christian Combs,Yuesheng Li,Alan T Remaley

Arteriosclerosis, Thrombosis, and Vascular Biology（2019）

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摘要

Familial hypercholesterolemia is caused by mutations in either LDL receptor (LDLR), ApoB-100, LDLRAP1, or PCSK9, but ~30% of patients lack these mutations, suggesting that unknown genes are also in...

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