Simulation of a batch crystallizer using a multi-scale approach in time and space

•Multi-scale simulation of growth-dominated crystallization in time and space.•Combining fast, 0-D QMOM simulations with 3-D unsteady CFD computations.•Leading to an improved prediction and understanding of crystal growth.•Stagnation region below the impeller strongly impacts local crystal properties.•Coupled 0-D/3-D model delivers superior prediction at acceptable computing time.