ANTI-ANALGESIC FORMULATION AND CHARACTERIZATION

Analgesics refers to group of medication preferably utilized for relieving pain and inflammation. Diclofenac sodium is a non-steroidal anti-inflammatory drug that is widely involved in pain reduction. The present paper aims to develop a topical nanoemulsion in combination with gel i.e. nanoemulgel formulation with potent anti-analgesic activity, wherein eucalyptus oil was mixed with diclofenac sodium along with tween-20 and butyl glycerol to develop an emulsion. The emulsion was then converted to gel by using carbomer as gelling agent. Finally, the nanoemulsion gel was subjected to characterization studies which include pH, viscosity, excrudability, spreadability and in vitro analysis. Skin irritation test was also performed for the formulation. The pH was found to be 5.49 ± 0.1 5 and viscosity was 2.20 ± 0.06 which is appropriate for the formulation. Also spreadability, excrudability co-efficients were 14.05 and 17.43 gm/cm2 respectively. There was no irritation or edema on application of the formulation on the skin.