Institution of prothrombin complex concentrate protocols is associated with a reduction in plasma administration at a Tertiary Care Hospital

•Plasma administration carries significant transfusion associated morbidity and mortality.•Four factor prothrombin complex concentrates (4F-PCC) may be more efficacious than plasma.•Using 4F-PCC decreased plasma use without increasing other blood product administration•Greatest reduction in plasma use in surgery followed by intensive care•4F-PCC increase less dramatic than reduction in plasma administration