Assessment of biocompatibility and surface topography of poly(ester urethane)–silica nanocomposites reveals multifunctional properties

•A bioglass poly(ester-urethane) nanocomposite scaffolds were obtained from P(3HB).•Raw and salt leached scaffolds were superficially characterized by several methods.•The nanocomposites allowed the attachment and viability of hBM-MSC and hDP-SC.••Induced porosity only affected the adhesion but not the biocompatibility of the cells.•The platforms allowed strain A. brasilense to form biofilms in a stressful environment.•The multifunctionality of poly(ester-urethane) nanocomposite scaffolds was shown.