Dextran sulphate inhibits an association of prions with plasma membrane at the early phase of infection

Takayuki Fuse,Takehiro Nakagaki,Takujiro Homma,Hiroya Tange,Naohiro Yamaguchi,Ryuichiro Atarashi,Daisuke Ishibashi,Noriyuki Nishida

Neuroscience Research（2021）

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摘要

•The attached PrPSc localizes into lipid rafts.•DS500 inhibits the attachment of PrPSc to the cell surface.•DS500 inhibits 22 L prion transmission in mouse neuroblastoma cells.

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关键词

Prion diseases,Cellular prion protein,Abnormal prion protein,Lipid rafts,Endocytosis

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