ALSUntangled 59: Tamoxifen THE ALSUNTANGLED GROUP

Richard Bedlack, James Stephens,Paul E Barkhaus,Michael Bereman,James B Caress,Jesse Crayle,Gary L Pattee,Terry Heiman Patterson,Paul Wicks,Neta Zach,Gregory T Carter,Kristiana Salmon

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION（2021）

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摘要

Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.

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关键词

Tamoxifen, ALSUntangled, off-label treatment, trials, ethics, therapy, clinical trials

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