Mass Spectrometry Reveals Potential Of Beta-Lactams As Sars-Cov-2 M-Pro Inhibitors

Tika R Malla,Anthony Tumber,Tobias John,Lennart Brewitz,Claire Strain-Damerell,C David Owen,Petra Lukacik,H T Henry Chan,Pratheesh Maheswaran,Eidarus Salah,Fernanda Duarte,Haitao Yang,Zihe Rao,Martin A Walsh,Christopher J Schofield

CHEMICAL COMMUNICATIONS（2021）

引用 27|浏览5

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摘要

The main viral protease (M-pro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry M-pro assay. The results reveal some beta-lactams, including penicillin esters, are active site reacting M-pro inhibitors, thus highlighting the potential of acylating agents for M-pro inhibition.

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