Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors.
CLINICAL PHARMACOLOGY & THERAPEUTICS（2021）
摘要
Entrectinib is well absorbed, with linear PK that is suitable for once-daily dosing, and can be taken with or without food.
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关键词
Bioequivalence,Entrectinib,Food effect,Pharmacokinetics,TRK/ROS1/ALK
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