Integrating metabolomics and network pharmacology to explore Rhizoma Coptidis extracts against sepsis-associated acute kidney injury
Journal of Chromatography B(2021)
Abstract
•SA-AKI was effectively alleviated with RCE treatment.•25 differential metabolites related to the pathological processes of SA-AKI and the effects of RCE were identified.•A compound-metabolite-target-disease network was constructed to explore the mechanisms of RCE against SA-AKI.•RCE may mitigate SA-AKI through regulating these 17 overlapping target proteins in the network.
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Key words
Rhizoma Coptidis,Sepsis,Acute kidney injury,Metabolomics,Network pharmacology
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