Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

Integrating metabolomics and network pharmacology to explore Rhizoma Coptidis extracts against sepsis-associated acute kidney injury

Yuenan Zheng,Xuan Shi,Jiebin Hou,Songyan Gao,Yufan Chao,Jiarong Ding,Long Chen,Yong Qian,Guojian Shao,Yachen Si,Wei Chen

Journal of Chromatography B（2021）

Cited 13|Views7
No score
Abstract
•SA-AKI was effectively alleviated with RCE treatment.•25 differential metabolites related to the pathological processes of SA-AKI and the effects of RCE were identified.•A compound-metabolite-target-disease network was constructed to explore the mechanisms of RCE against SA-AKI.•RCE may mitigate SA-AKI through regulating these 17 overlapping target proteins in the network.
More
Translated text
Key words
Rhizoma Coptidis,Sepsis,Acute kidney injury,Metabolomics,Network pharmacology
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined