Development of a simple and rapid UPLC-MS/MS method for determination of 8-deacetyl-yunaconitine in rat plasma and its application to pharmacokinetics

Journal of Pharmaceutical and Biomedical Analysis（2021）

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摘要

•First reported of determination of 8-deacetyl-yunaconitine in rat plasma by UPLC-MS/MS.•First reported of pharmacokinetic study of 8-deacetyl-yunaconitine after oral and intravenous administration in rat.•It only takes 3 min to complete the analysis of one plasma sample.

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关键词

Pharmacokinetics,8-deacetyl yunaconitine,Bioavailability,Rat,UPLC-MS/MS

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