ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis
Journal of Molecular Biology(2021)
Abstract
•ClpXP1P2 is involved in the TAC activation cycle.•Last two residues of the HigA1 antitoxin are essential for ClpXP1P2 recognition.•Chaperone-addiction region functions as a hub for chaperone and protease binding.
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Key words
Toxin-antitoxin,HigB1-HigA1,SecB,ClpX,ClpC1
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