An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responses

Golbarg Rahimi,Bahareh Rahimi,Mohammad Panahi,Shadi Abkhiz,Neda Saraygord-Afshari,Morteza Milani,Effat Alizadeh

International Immunopharmacology（2021）

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摘要

•MERS-CoV, SARS-CoV-1/2 as members of β-CoVs family have many similar pathogenicity.•Frequency of emerging β-CoVs infections reported in males are higher than females.•Sex-hormones and X-chromosome related genes may be the cause of these sex differences.•Immune response of women might protect further against MERS, SARS-CoV1/2 infections.•Sex-based immune-responses may provide new insights for upcoming immunotherapies.

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Coronavirus,SARS,MERS,SARS-CoV-2,COVID-19,Respiratory infection,Immune response,Male,Female

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