High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody

Leukemia Research(2011)

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Abstract
The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1pos BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1pos ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry.
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Key words
Drebrin,Acute lymphoblastic leukemia,Gene expression profiling,TEL/AML1,Flow cytometry,Monoclonal antibody,Immunophenotyping
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