The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats.

Maria Donatella Semeraro,Antonio Paolo Beltrami, Feras Kharrat,Gunter Almer,Simon Sedej,Wilfried Renner,Hans-Jürgen Gruber,Francesco Curcio,Markus Herrmann

Frontiers in cardiovascular medicine（2022）

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摘要

HFD-induced obesity showed no effects on myocardial telomeres and induced only mild morphologic alterations. Summarized, long-term moderate endurance exercise partially reverses HFD-induced effects but may even trigger cardiac remodeling in the context of obesity.

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关键词

Sprague-Dawley rats,cardiomyocyte senescence,cardiovascular remodeling,high-fat diet,moderate endurance exercise,shelterin,telomerase,telomere length

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